Real‐life experience with oral oxybutynin long‐term continuous therapy in severe hyperhidrosis and systematic review of the literature
نویسندگان
چکیده
Hyperhidrosis is a disorder of excessive sweating severely impacting on patient's quality life (Qol). Several studies have been published about oral oxybutynin, but no focused the achievement complete clinical and Qol response. The aim this study was to report our real-life experience with oxybutynin in patients severe hyperhidrosis significantly affecting their Qol. In cohort retrospective study, we enrolled, 3-year period, affected by poor Qol, continuously treated oxybutynin. Our outcome obtainment improvement. A systematic review literature also performed reporting efficacy safety for primary hyperhidrosis. We enrolled 62 patients, which 53 (85.5%) received mean daily dose 10 mg nine (15.5%) 5 mg. Complete response achieved 77.4% (48/62) cases, while improvement occurred 51.6% (32/62) cases. Adverse events were only reported as mild, dry mouth being most frequently observed (16.1%). Kaplan-Meier survival analysis highlighted that both median responses reached after 1 year continuous therapy main limitation small number enrolled. Long-term hyperhidrosis, administered at dosage mg, allowed majority reach improvement, without significant adverse events.
منابع مشابه
Treatment of uncommon sites of focal primary hyperhidrosis: experience with pharmacological therapy using oxybutynin
OBJECTIVES Primary hyperhidrosis usually affects the hands, armpits, feet and cranio-facial region. Sweating in other areas is common in secondary hyperhidrosis (after surgery or in specific clinical conditions). Oxybutynin has provided good results and is an alternative for treating hyperhidrosis at common sites. Our aim was to evaluate the efficacy of oxybutynin as a treatment for primary swe...
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15 صفحه اولLiterature review in the treatment of calciphylaxis:A case with uncontrolled and severe secondary hyperparathyroidism
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ژورنال
عنوان ژورنال: Dermatologic Therapy
سال: 2021
ISSN: ['1529-8019', '1396-0296']
DOI: https://doi.org/10.1111/dth.14832